With Rebirth and now Afterbirth, a lot of new pills were added to the game, many of them not particularly great or even all that interesting. A lot of these pills are "neutral pills", meaning they have no good or bad equivalent and are thus not improved by picking up the PHD item, even though in some cases they are objectively bad.

This mod attempts to fix some of these issues by removing pills to make the selection better. You will still have thirteen pill types available on each run as normal, but the pool from which they draw is reduced according to your preference. There are five different options (a more detailed list of pills removed is in the download):

• Lite - Removes all neutral pills that are negative and/or have no effect on gameplay.
  


• Lite+ - Same as Lite, but also removes neutral pills that technically have a use but do nothing interesting and make very little difference to your run. This is the one I personally go with.
  


• Full - Removes all neutral pills, period. This includes every pill that doesn't have a good or bad equivalent, both potentially negative, like Hematemesis, or objectively positive, like 48 Hour Energy. This reduces the selection to fourteen, meaning all but one pill will be in play in each run. You're likely to get a lot of stat downs with this, and PHD is at its strongest here. Note that this removes Full Health as its own pill, but you can still get it by being at low health with Bad Trip.
  


• Classic - Sets the pill selection to that used in Wrath of the Lamb Isaac, minus Puberty, since it used to share a pill with I Found Pills.
  


• Casual - Makes every pill good by removing all pills with no effect on gameplay or a potentially negative effect. PHD is all but useless, but it's not like you need it now.

Thanks to Wofsauge, who worked out the method to remove pills. See their mod here that removes only the Retro Vision Pill. Apologies for the lack of good screenshots - I'm not sure how to picture things not being there?

Installation:

Open up the downloaded zip file. Extract the contents of version you want into The Binding of Isaac Rebirth/resources. To uninstall and restore the pills, simply delete the extracted file.